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Arsenic trioxide side effects

Side effects not requiring immediate medical attention Belching bone pain feeling of warmth heartburn heavy non-menstrual vaginal bleeding injection site pain, redness, or swelling limb pain mental depression neck pain nosebleeds redness of the face, neck, arms, and occasionally, upper chest trouble. COMMON side effects If experienced, these tend to have a Severe expression i . low amount of magnesium in the blood ; low amount of calcium in the blood ; acidosis, a high level of acid in the bloo Possible Side Effects of Arsenic Trioxide (Table Version Date: April 10, 2019) COMMON, SOME MAY BE SERIOUS: In 100 people receiving Arsenic Trioxide, more than 20 and up to 100 may have: Change in the heart rhythm. Low blood pressure which may cause feeling faint. Swelling of the body There is no relationship between the presence or severity of side effects and the effectiveness of the medication. The following side effects are common (occurring in greater than 30%) for patients taking arsenic trioxide: Nausea and vomiting. Cough Arsenic trioxide may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as..

Arsenic trioxide Side Effects: Common, Severe, Long Term

Arsenic trioxide side effects Get emergency medical help if you have signs of an allergic reaction: hives ; difficult breathing; swelling of your face, lips, tongue, or throat. Arsenic trioxide can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated Side effects. We haven't listed all the side effects. It's very unlikely that you will have all of these side effects, but you might have some of them at the same time. How often and how severe the side effects are can vary from person to person. They also depend on what other treatments you're having

Common and Rare Side Effects for arsenic trioxide intravenou

  1. ed. Careful attention to the clinical management of patients on arsenic trioxide therapy can significantly lessen the risk of major side effects
  2. What are the side effects of Arsenic Trioxide (Trisenox)? Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or..
  3. Common side effects include vomiting, diarrhea, swelling, shortness of breath, and headaches. Severe side effects may include APL differentiation syndrome and heart problems. Use during pregnancy or breastfeeding may harm the baby. Arsenic trioxide has the formula A
  4. Postmarketing side effects of arsenic trioxide reported include: Cardiac disorders: Ventricular extrasystoles in association with QT prolongation, ventricular tachycardia in association with QT prolongation, including torsade de pointes, atrioventricular block, and congestive heart failur
  5. Arsenic trioxide may cause QT prolongation (heart muscles take longer to recharge between beats due to an electrical disturbance), which can cause serious or life-threatening heart rhythm problems
  6. Description: Arsenic trioxide, an antineoplastic agent, induces apoptosis by causing morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells. It also damages and degrades promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-α fusion gene, a characteristic of APL
  7. Additionally, this medication often causes a condition known as QT prolongation, which affects the rhythm of the heart, so your doctor has to know if you have a history of heart problems. You should also tell your doctor if you have low magnesium and potassium blood levels so that the medication does not trigger any unwanted side effects

  1. In clinical studies, the most commonly reported side effects with ATRA (Tretinoin) + Arsenic Trioxide are shown here: A note about side effect percentages Liver dysfunction (63%) Heart rhythm abnormalities (16%
  2. al pain; alveolar haemorrhage; anaemia; arrhythmias; arthralgia; chest pain; chills; diarrhoea; differentiation syndrome; dizziness; dyspnoea; electrolyte imbalance; fatigue; fever; headache; hyperbilirubinaemia; hyperglycaemia; hypotension; hypoxia; increased risk of infection; ketoacidosis; leucocytosis; myalgia
  3. Author: HHS/DCTD/CTEP Created Date: 01/24/2018 08:09:00 Title: Possible Side Effects of Arsenic Trioxide Subject: Possible Side Effects of Arsenic Trioxide

Arsenic Trioxide Drug Information - Chemocare - Side Effect

What is Trisenox and how is it used? Trisenox (arsenic trioxide) is a cancer medication used to treat a cancer of the blood and bone marrow called acute promyelocytic leukemia, or APL.What are side effects of Trisenox? Common side effects of Trisenox include: injection site reactions (pain, redness, or swelling) What are the possible side effects of arsenic trioxide (Trisenox)? Get emergency medical help if you have signs of an allergic reaction : hives ; difficult breathing; swelling of your face, lips, tongue, or throat Long-term effect of all-trans retinoic acid and arsenic trioxide sequential maintenance in patients with acute promyelocytic leukemia. Leuk Lymphoma. 2019 Mar;60 (3):711-719. doi: 10.1080/10428194.2018.1504941. Epub 2018 Nov 8

Arsenic Trioxide Intravenous: Uses, Side Effects

  1. Arsenic Trioxide. Arsenic trioxide is already an established, approved drug against relapsed acute promyelocytic leukaemia for remission induction. From: Side Effects of Drugs Annual, 2014. Related terms: Flecainide; Arsenic Compounds; Disopyramide; Tretinoin; Chemotherapy; Apoptosis; Telithromycin; Autophagy; QT Interval; Protei
  2. istrated, some adverse side effects have been reported recently
  3. Arsenic trioxide belongs to a group of drugs called antineoplastics. These work by slowing or stopping the growth of cancer cells. This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional. Common side effects include nausea, tiredeness, fever, and swelling

Arsenic trioxide side effects Arsenic trioxide dosing information What other drugs [] تسجيل الدخول الأربعاء, يونيو 16, 2021; الصفحة الرئيسية; خدمات. Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. It is usually given once a day for a specific period of time

In a multi-drug regimen, each medication has unique side effects. When these medicines are given together, drug-related side effects reported in clinical studies give the best estimate of what to expect. In clinical studies, the most commonly reported side effects of ATRA + arsenic trioxide consolidation are shown here License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only

Video: Arsenic trioxide Uses, Side Effects & Warnings - Drugs

Arsenic trioxide- Common side effects include Differentiation syndrome (shortness of breath, fever, sudden weight gain, increased white blood cells), Electrolyte imbalances, Nausea, vomiting, diarrhoea, raised liver enzymes, heart abnormalitie 1 Zhou, Jin. Effects of arsenic trioxide on voltage-dependent potassium channels and on cell proliferation of human multiple myeloma cells. Chinese Medical Journal 120.14 (2009): 1266-1269. Web. 22 Apr 2011

Arsenic trioxide (Trisenox, ATO) Cancer information

Arsenic trioxide is a chemotherapeutic or antineoplastic agent which targets the enzyme thioredoxin reductase and causes morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells.It also breaks down and disrupts the fusion of promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha, thus inducing cancer cells to undergo apoptosis help manage the side effects are included. SIDE EFFECTS MANAGEMENT Allergic reactions may rarely occur. Signs of an allergic reaction may include flushing, rash, itching, dizziness, swelling or breathing problems. Tell your nurse if this happens while you are receiving arsenic trioxide or contact your oncologist immediately if thi

Arsenic Trioxide Intravenous: Uses, Side Effects

The most common side effects of arsenic trioxide were gastrointestinal. Adverse events subsided spontaneously or with symptom-based interventions and did not require suspension of treatment (1). Additional studies conducted in the United States confirmed tha Arsenic trioxide is in a class of medications called anti-neoplastics. It works by slowing or stopping the growth of cancer cells. Side Effects of Arsenic Trioxide Arsenic trioxide injection may cause an increase in your blood sugar. Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar)

Arsenic trioxide - PubMe

  1. Arsenic trioxide Mylan is used to treat adults (aged 18 years or over) with acute promyelocytic leukaemia (APL), a rare form of leukaemia (cancer of the white blood cells) caused by a genetic 'translocation' (when there is a swap of genes between two chromosomes). The translocation affects the way the white blood cells grow, and as a result.
  2. Arsenic poisoning, or arsenicosis, occurs after the ingestion or inhalation of high levels of arsenic. Arsenic is a type of carcinogen that's gray, silver, or white in color. Arsenic is.
  3. imal side effects [13]. Data from various studies shows that arsenic trioxide may be a useful addition to the therapeutic regimens that have been so successful in treating newly diagnose
  4. Arsenic Trioxide is used for Blood Cancer, Acute Promyelocytic Leukemia etc. Know Arsenic Trioxide uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.co

Arsenic Trioxide (Trisenox) - Side Effects, Interactions

Acute promyelocytic leukaemia (APL) is commonly treated with arsenic trioxide (As2O3) that has many side effects. Given the increasing trend of studies on beneficial therapeutic properties of synthetic compounds containing vanadium, the present study sought to use Schiff base oxovanadium complex to reduce the needed concentration of arsenic trioxide. The HL-60 cell line, which is a model of. Arsenic trioxide (ATO), a component of the traditional Chinese medicine arsenic sublimate, promotes apoptosis and induces leukemic cell differentiation. Combined with all-trans-retinotic acid (ATRA), ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APL). The most common side effects of ATO include hepatotoxicity, gastrointestinal symptoms, water-sodium. General Information Description. Arsenic compounds exist in a number of inorganic and organic forms. This Medical Management Guideline focuses on arsenic trioxide (As 2 O 3), one of the most toxic and prevalent forms.Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially nontoxic However, glioma cells and tissues from various sources have different responses to arsenic trioxide, and it has some limitations and side effects in tumor therapy [8,9,10]. Research in this area is increasingly focused on combinations of arsenic trioxide with other drugs or methods to enhance its anti-glioma efficacy and reduce adverse reactions Arsenic trioxide Accord is usually given by a doctor or nurse. It is given as a drip (an infusion ) into a vein for 1-2 hours, but it may take longer if side effects such as redness and dizziness occur. Arsenic trioxide Accord should not be mixed with or passed through, the same tube along with other drugs

Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. Long-term exposure can result in thickening of the skin, darker skin, abdominal pain, diarrhea, heart disease, numbness, and cancer N.H. Choulis, in Side Effects of Drugs Annual, 2014. Arsenic Trioxide. Arsenic trioxide has long been of biomedical interest and is still used to treat cancer and other conditions. It is a chemotherapeutic agent of idiopathic function used to treat leukaemia that is unresponsive to 'first-line' agents Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported. In this manuscript, we investigated 23 APL.. Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported

Arsenic trioxide - Wikipedi

Ventricular tachyarrhythmias may occur during intravenous arsenic trioxide (As 2 O 3).This has not happened during oral As 2 O 3.Sixteen patients were studied by electrocardiography and 24-hour Holter monitoring at baseline, during and after oral As 2 O 3 (As 2 O 3-ON, As 2 O 3-OFF).QT and corrected QT (QTc) were significantly longer during As 2 O 3-ON than in As 2 O 3-OFF, but QT and QTc. WARNING: Arsenic trioxide is a strong medication that can cause serious, rarely fatal side effects. To decrease your risk, your doctor will monitor you closely during treatment. To decrease your risk, your doctor will monitor you closely during treatment

Arsenic Trioxide Intravenous : Uses, Side Effects

Side effects of arsenic trioxide may include insomnia. The most common way to use arsenic trioxide for medical uses is through injection into a vein. It is usually in a powder form, but once it is converted into a liquid, a doctor or nurse may inject the drug over a one to four hour period However, due to toxic side effects of long-term heroic-dose of oral arsenic in most patients, and with the advent of modern radiotherapy and chemotherapy, the arsenic treatment for CML was given. Arsenic trioxide Mylan is used in adult patients with newly diagnosed acutepromyelotic leukemia (APL) with low to intermediate risk, as well as in adult patients when the disease has not improved after other treatments. APL is a unique form of myeloid leukemia, a disease in which abnormal white blood cells are produced and abnormal bleeding and bruising occur Side effects were mostly hematological and cutaneous (one grade 3) and reversible with dose reduction of AZT/IFN and/or As2O3 discontinuation. The virus integration analysis revealed the regression of the predominant malignant clone in one patient with a chronic subtype Arsenic trioxide belongs to the general group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by arsenic trioxide, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor

Arsenic Trioxide (Trisenox): Side Effects, Dosages

  1. WARNING: Arsenic trioxide is a strong medication that can cause serious, rarely fatal side effects. To decrease your risk, your doctor will monitor you closely during treatment.Rarely, this medication may cause a serious condition called APL differentiation syndrome
  2. Side-effects, further information. Signs and symptoms of differentiation syndrome (leucocyte activation syndrome) include unexplained fever, dyspnoea, weight gain, pulmonary infiltrates, pleural or pericardial effusions, with or without leucocytosis—treat with high dose corticosteroids, consult product literature
  3. Arsenic trioxide is a successful anti-leukemia drug without serious side effects 22,23. This feature may be common to AS6 and arsenic trioxide. This feature may be common to AS6 and arsenic trioxide
  4. Arsenic Trioxide के नुकसान, दुष्प्रभाव और साइड इफेक्ट्स - Arsenic Trioxide Side Effects in Hindi . रिसर्च के आधार पे Arsenic Trioxide के निम्न साइड इफेक्ट्स देखे गए हैं
Trisenox intravenous: Uses, Side Effects, Interactions

Trisenox (arsenic trioxide) Chemotherapy, Side Effects

What are the possible side effects of arsenic trioxide? Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Arsenic trioxide can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated Arsenic trioxide Warnings Arsenic trioxide is a strong medication that can cause serious, rarely fatal side effects. To decrease your risk, your doctor will monitor you closely during treatment. Rarely, this medication may cause a serious condition called APL differentiation syndrome

Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsedpatients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses as well as arsenites or arsenates of sodium, calcium, and potassium. Arsenic trioxide is an inorganic form of arsenic and is the most widely studied arsenical-based cancer drug. 1. Although its mechanism is not completely understood, arsenic trioxide may have a multi-modal mechanism of action likely dependent on dose. At lower doses, arsenic

Arsenic trioxide: Indication, Dosage, Side Effect

Trisenox - FDA prescribing information, side effects and uses

TRISENOX is a sterile injectable solution of arsenic trioxide. The molecular formula of arsenic trioxide in the solid state is As 2 O 3, with a molecular weight of 197.8 and the following structural formula: TRISENOX is available in 10 mL, single-dose vials containing 12 mg of arsenic trioxide What are the side effects of arsenic trioxide injections? Stacy Wiegman, PharmD. Pharmacy. Arsenic trioxide (Trisenox) is used to treat a type of blood cancer known as acute promyelocytic leukemia (APL). This drug may cause a serious or life-threatening group of symptoms called APL differentiation syndrome Arsenic trioxide is also being studied in the treatment of other types of cancer. More About Arsenic Trioxide. possible side effects. Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug The arsenic trioxide prevents the cancer cells from multiplying and can keep cancer cells from being supplied with necessary nutrients that are involved in feeding their growth. Side effects of Arsenic Trioxide: The most commonly occurred arsenic trioxide side effects are listed as follows

SUMMARY OF ARSENIC TRIOXIDE CLINICAL TRIALS IN MULTIPLE

Find treatment reviews for Arsenic Trioxide from other patients. Learn from their experiences about effectiveness, side effects and cos Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. Dose. Adults and children five years of age and older: Induction, 0.15 mg per kg of body weight daily until bone marrow remission occurs (up to 60 doses). Consolidation, 0.15 mg per kg of body weight daily for 25 doses over a period of up to five weeks Despite the beneficial effects of chelating agents against arsenic toxicity, they have some drawbacks, such as non-specificity, low therapeutic index, failure to permeate the plasma membrane and metal redeployment, and induce side effects including headache, nausea, and vomiting, thus their use has been limited. Although these chelating agents. Arsenic trioxide is a cancer medication. Arsenic trioxide interferes with the growth of cancer cells and slows their growth and spread in the body. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. Arsenic trioxide may also be used for other purposes not.

Ambient drug | each drug has its own unique manifestations

In one report from China, arsenic trioxide monotherapy produced complete clinical responses in 9 of 10 patients with relapsed APL . Treatment was not associated with bone marrow suppression and produced only limited side effects. The results of these observational studies have been confirmed in randomized clinical trials in the U.S. [13, 14. The form of arsenic found naturally in foods (organic arsenic) does not seem to cause any harm.at a level of 50 mcg/L has been linked to reduced scores on intelligence tests in children. Also, arsenic trioxide is LIKELY SAFE when given intravenously (by IV) to adults by a healthcare provider. It is an FDA-approved prescription drug

Synergism between Arsenic Trioxide and Heat Shock ProteinPHARMACEUTICAL MEDICINE - Arsenox(Arsenic Trioxide

Unusual Effects of a QT-Prolonging Drug, Arsenic Trioxide, on Cardiac Potassium Currents Benoit Drolet, PhD; Chantale Simard, PhD; Dan M. Roden, MD Background—Cases of QT prolongation, torsades de pointes, and sudden death have been reported with arsenic trioxide (As2O3), a highly effective agent for acute promyelocytic leukemia Arsenic Trioxide Side Effects What are the possible side effects of Arsenic Trioxide? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as Background— Cases of QT prolongation, torsades de pointes, and sudden death have been reported with arsenic trioxide (As 2 O 3), a highly effective agent for acute promyelocytic leukemia.In this study, we evaluated the effects of As 2 O 3 on repolarizing cardiac ion currents.. Methods and Results— In HERG- or KCNQ1+KCNE1-transfected CHO cells (n=32; total), As 2 O 3 caused concentration. Arsenic trioxide is approved to be used with tretinoin to treat: Acute promyelocytic leukemia actions, lung, or side effects of this drug, Might even low doses of arsenic, In 100 people receiving Arsenic Trioxide, neck pain, Long-term exposure to high levels of inorganic arsenic in drinking water is associated with certain medical conditions Carcinogenesis: The active ingredient of TRISENOX, arsenic trioxide, is a human carcinogen. Monitor patients for the development of second primary malignancies. Embryo-Fetal Toxicity: TRISENOX can cause fetal harm when administered to a pregnant woman. One patient who became pregnant while receiving arsenic trioxide had a miscarriage Learn about the potential side effects of arsenic trioxide. Arsenic trioxide Side Effects. Overview; Side. sepsis, earache, tinnitus, chills Frequency not. KOLKATA: As part of its plan to provide citizens arsenic-free water and impose a total ban on. Get latest news & live updates on the go on your pc with News App. Download The Times of India.